Symbol
Name
ID

Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
MGI:1099800

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased circulating IgA level	Decreased circulating IgG level	Decreased circulating total IgM
Disease(s) Associated with NFKB2
common variable immunodeficiency 10

Mouse Phenotypes

hematopoietic system phenotype

increased splenocyte apoptosis

abnormal osteoclast differentiation

decreased B cell proliferation

increased B cell proliferation

increased T cell proliferation

abnormal thymus cell ratio

abnormal thymus corticomedullary boundary morphology

abnormal thymus size

thymus atrophy

abnormal thymus physiology

enlarged spleen

increased spleen weight

abnormal definitive hematopoiesis

abnormal B cell differentiation

abnormal class switch recombination

decreased transitional stage B cell number

decreased transitional stage T2 B cell number

increased transitional stage B cell number

abnormal plasma cell differentiation

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

increased double-negative T cell number

decreased double-positive T cell number

increased double-positive T cell number

extramedullary hematopoiesis

anemia

increased granulocyte number

decreased myeloid dendritic cell number

increased plasmacytoid dendritic cell number

decreased dendritic cell number

abnormal lymphocyte cell number

decreased mature B cell number

decreased B-2 B cell number

decreased follicular B cell number

decreased marginal zone B cell number

increased B-1 B cell number

increased B-1a cell number

decreased B cell number

decreased NK cell number

abnormal T cell subpopulation ratio

abnormal T cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

decreased effector memory CD8-positive, alpha-beta T cell number

increased CD8-positive, naive alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased gamma-delta T cell number

increased T cell number

increased lymphocyte cell number

abnormal myeloid dendritic cell morphology

abnormal gamma-delta T cell morphology

abnormal metallophilic macrophage morphology

abnormal spleen marginal zone macrophage morphology

abnormal spleen morphology

increased spleen red pulp amount

intermingled spleen red and white pulp

decreased spleen weight

spleen atrophy

spleen hypoplasia

abnormal spleen white pulp morphology

abnormal spleen B cell follicle morphology

abnormal spleen follicular dendritic cell network

abnormal spleen primary B follicle morphology

abnormal spleen secondary B follicle morphology

absent spleen germinal center

abnormal spleen marginal zone morphology

absent spleen marginal zone

abnormal spleen periarteriolar lymphoid sheath morphology

abnormal immunoglobulin level

decreased IgA level

decreased IgG1 level

decreased IgG2a level

increased IgG2a level

decreased IgG2b level

decreased IgG3 level

decreased IgM level

increased IgM level

decreased immunoglobulin level

Availability

Mouse Genotype

Nfkb2^Lym1/Nfkb2^Lym1

Nfkb2^m2Btlr/Nfkb2^m2Btlr

Nfkb2^m3Btlr/Nfkb2^m3Btlr

Nfkb2^M4Btlr/Nfkb2^M4Btlr

Nfkb2^m5Btlr/Nfkb2^m5Btlr

Nfkb2^tm1Brv/Nfkb2^tm1Brv

Nfkb2^tm1Rsch/Nfkb2^tm1Rsch

Nfkb2^tm1Sbn/Nfkb2^tm1Sbn

Nfkb2^tm2Brv/Nfkb2^tm2Brv

Nfkb2^xdr/Nfkb2^xdr

Nfkb2^Lym1/Nfkb2⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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